A New FOXO Pathway Required for Leukemogenesis
نویسنده
چکیده
In cancer, the FOXO family of transcription factors functions as tumor suppressors and is directly inactivated by oncogenic signaling through the PI3K/AKT pathway. Now, Skykes et al. (2011) identify a paradoxical requirement for FOXOs in the maintenance of leukemia-initiating cells.
منابع مشابه
Targeting forkhead box transcription factors FOXM1 and FOXO in leukemia (Review).
Deregulation of forkhead box (FOX) proteins has been found in many genetic diseases and malignancies including leukemia. Leukemia is a common neoplastic disease of the blood or bone marrow characterized by the presence of immature leukocytes and is one of the leading causes of death due to cancer. Forkhead transcription factors, FOXM1 and FOXO family members (FOXOs), are important mediators in ...
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عنوان ژورنال:
- Cell
دوره 146 شماره
صفحات -
تاریخ انتشار 2011